Grietje Molema Selected Research

E-Selectin

12/2019	Markers of endothelial cell activation in suspected late onset neonatal sepsis in Surinamese newborns: a pilot study.
12/2015	Histone Deacetylase Inhibition and IκB Kinase/Nuclear Factor-κB Blockade Ameliorate Microvascular Proinflammatory Responses Associated With Hemorrhagic Shock/Resuscitation in Mice.
1/2014	Effective siRNA delivery to inflamed primary vascular endothelial cells by anti-E-selectin and anti-VCAM-1 PEGylated SAINT-based lipoplexes.
8/2013	Anti-VCAM-1 and anti-E-selectin SAINT-O-Somes for selective delivery of siRNA into inflammation-activated primary endothelial cells.
9/2011	Hemorrhagic shock-induced endothelial cell activation in a spontaneous breathing and a mechanical ventilation hemorrhagic shock model is induced by a proinflammatory response and not by hypoxia.
6/2010	Targeted SAINT-O-Somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cells.
1/2009	Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis.
3/2008	Inhibition of proinflammatory genes in anti-GBM glomerulonephritis by targeted dexamethasone-loaded AbEsel liposomes.
2/2008	Early organ-specific endothelial activation during hemorrhagic shock and resuscitation.
7/2007	Site-specific inhibition of glomerulonephritis progression by targeted delivery of dexamethasone to glomerular endothelium.

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Grietje Molema Research Topics

Disease

28	Neoplasms (Cancer) 12/2019 - 01/2002
23	Inflammation (Inflammations) 07/2021 - 02/2002
13	Sepsis (Septicemia) 01/2022 - 01/2009
8	Hemorrhagic Shock 01/2019 - 02/2008
6	Acute Kidney Injury (Acute Renal Failure) 07/2021 - 07/2012
5	Shock 10/2014 - 02/2008
5	Hypoxia (Hypoxemia) 09/2011 - 04/2006
3	Critical Illness (Critically Ill) 10/2019 - 01/2009
3	Endotoxemia 01/2018 - 01/2009
3	Body Weight (Weight, Body) 12/2015 - 01/2011
3	Hepatocellular Carcinoma (Hepatoma) 01/2014 - 11/2008
3	Glioblastoma (Glioblastoma Multiforme) 11/2012 - 01/2009
3	Melanoma (Melanoma, Malignant) 02/2012 - 02/2005
3	Glomerulonephritis 02/2011 - 07/2007
3	Infections 09/2004 - 01/2002
2	Neoplasm Metastasis (Metastasis) 01/2012 - 09/2002
2	Cicatrix (Scar) 05/2011 - 09/2010
2	Hyperglycemia 01/2011 - 09/2008
2	Vascular Remodeling 08/2010 - 04/2010
2	Liver Cirrhosis (Hepatic Cirrhosis) 06/2010 - 03/2006
2	Rheumatoid Arthritis 09/2006 - 01/2006
2	Carcinoma (Carcinomatosis) 02/2005 - 08/2003
2	Necrosis 01/2005 - 09/2004
1	Bacteremia 12/2019
1	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 10/2019
1	Renal Cell Carcinoma (Grawitz Tumor) 12/2018
1	Kidney Neoplasms (Kidney Cancer) 12/2018

Drug/Important Bio-Agent (IBA)

15	Proteins (Proteins, Gene)FDA Link 10/2019 - 01/2002
14	E-SelectinIBA 12/2019 - 04/2002
11	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2012 - 11/2004
9	Messenger RNA (mRNA)IBA 10/2019 - 05/2007
8	Angiopoietin-2IBA 12/2017 - 09/2008
7	Pharmaceutical PreparationsIBA 01/2022 - 02/2005
7	Angiopoietin-1IBA 12/2017 - 01/2009
7	Small Interfering RNA (siRNA)IBA 01/2015 - 11/2004
6	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 12/2015 - 10/2005
6	Liposomes (Liposome)IBA 12/2012 - 02/2002
5	Dexamethasone (Maxidex)FDA LinkGeneric 01/2018 - 11/2002
5	AngiopoietinsIBA 01/2015 - 11/2008
5	CytokinesIBA 10/2014 - 09/2004
5	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 09/2011 - 04/2002
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2021 - 04/2002
4	AntibodiesIBA 07/2014 - 04/2002
4	arginyl-glycyl-aspartic acidIBA 09/2007 - 10/2002
4	IntegrinsIBA 04/2006 - 09/2002
3	Phosphotransferases (Kinase)IBA 01/2022 - 02/2012
3	LipopolysaccharidesIBA 12/2018 - 04/2006
3	cadherin 5IBA 01/2017 - 02/2008
3	Histone Deacetylase InhibitorsIBA 12/2015 - 11/2006
3	Histones (Histone)IBA 12/2015 - 11/2006
3	Angiogenesis InhibitorsIBA 12/2012 - 10/2002
3	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 12/2012 - 11/2004
3	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA 02/2012 - 11/2004
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 08/2010 - 01/2005
3	EpitopesIBA 03/2008 - 09/2002
3	DNA (Deoxyribonucleic Acid)IBA 05/2007 - 04/2006
3	Peptides (Polypeptides)IBA 10/2002 - 01/2002
2	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 01/2022 - 07/2006
2	CreatinineIBA 10/2019 - 11/2003
2	GlucocorticoidsIBA 01/2018 - 02/2005
2	TIE-2 Receptor (Receptor, TIE 2)IBA 12/2017 - 12/2010
2	Histone Deacetylases (Histone Deacetylase)IBA 12/2015 - 05/2007
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2014 - 03/2009
2	Oxygen (Dioxygen)IBA 12/2012 - 01/2009
2	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 04/2012 - 01/2009
2	Immunoglobulin G (IgG)IBA 02/2011 - 04/2002
2	Retinaldehyde (Retinal)IBA 01/2011 - 07/2009
2	Caspase 3 (Caspase-3)IBA 06/2010 - 01/2009
2	salicylhydroxamic acid (SHAM)IBA 09/2009 - 02/2008
2	Vascular Endothelial Growth Factor DIBA 01/2009 - 04/2006
2	AlbuminsIBA 09/2007 - 11/2006
2	Decitabine FDA Link 05/2007 - 11/2006
2	trichostatin A (A 300)IBA 05/2007 - 11/2006
2	Cell Adhesion MoleculesIBA 11/2006 - 11/2003
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 07/2006 - 04/2006
2	Atorvastatin (Lipitor)FDA Link 07/2006 - 04/2006
2	LactoferrinIBA 09/2004 - 01/2002
2	Doxorubicin (Adriamycin)FDA LinkGeneric 08/2003 - 09/2002
2	Antiviral Agents (Antivirals)IBA 04/2003 - 01/2002
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2022
1	SelectinsIBA 12/2019
1	MicroRNAs (MicroRNA)IBA 12/2019
1	Lipocalin-2IBA 10/2019
1	Biomarkers (Surrogate Marker)IBA 10/2019
1	FibrinIBA 12/2018
1	EnzymesIBA 01/2018
1	SialomucinsIBA 01/2017
1	Claudin-5IBA 01/2017
1	OccludinIBA 01/2017
1	3- (4- methylphenylsulfonyl)- 2- propenenitrileIBA 12/2015
1	Human Serum Albumin FDA LinkGeneric 12/2015

Therapy/Procedure

9	Therapeutics 01/2022 - 09/2002
5	Resuscitation 01/2019 - 02/2008
4	Cardiopulmonary Bypass (Heart-Lung Bypass) 07/2021 - 09/2010
3	Nephrectomy 10/2019 - 12/2018
2	Lasers (Laser) 12/2019 - 10/2019
2	Artificial Respiration (Mechanical Ventilation) 09/2011 - 12/2010
2	Anesthesia 09/2009 - 02/2008
2	Intravenous Administration 03/2008 - 11/2004
1	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 07/2021